A robust in vitro model for trans-lymphatic endothelial migration
Identifieur interne : 000832 ( Main/Exploration ); précédent : 000831; suivant : 000833A robust in vitro model for trans-lymphatic endothelial migration
Auteurs : Yanbao Xiong [États-Unis] ; C. Colin Brinkman [États-Unis] ; Konrad S. Famulski [Canada] ; Emmanuel F. Mongodin [États-Unis] ; Colin J. Lord [États-Unis] ; Keli L. Hippen [États-Unis] ; Bruce R. Blazar [États-Unis] ; Jonathan S. Bromberg [États-Unis]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Trans-endothelial migration (TEM) is essential for leukocyte circulation. While much is known about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migration. We established an
Url:
DOI: 10.1038/s41598-017-01575-w
PubMed: 28487567
PubMed Central: 5431648
Affiliations:
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Mongodin</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2175 4264</institution-id><institution-id institution-id-type="GRID">grid.411024.2</institution-id><institution>Institute for Genome Sciences,</institution><institution>University of Maryland School of Medicine,</institution></institution-wrap>Baltimore, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baltimore</wicri:regionArea></affiliation></author><author><name sortKey="Lord, Colin J" sort="Lord, Colin J" uniqKey="Lord C" first="Colin J." last="Lord">Colin J. Lord</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id><institution-id institution-id-type="GRID">grid.17635.36</institution-id><institution>University of Minnesota Cancer Center and the Department of Pediatrics,</institution><institution>Division of Blood and Marrow Transplantation, University of Minnesota,</institution></institution-wrap>Minneapolis, 55455 USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Minneapolis</wicri:regionArea></affiliation></author><author><name sortKey="Hippen, Keli L" sort="Hippen, Keli L" uniqKey="Hippen K" first="Keli L." last="Hippen">Keli L. Hippen</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000000419368657</institution-id><institution-id institution-id-type="GRID">grid.17635.36</institution-id><institution>University of Minnesota Cancer Center and the Department of Pediatrics,</institution><institution>Division of Blood and Marrow Transplantation, University of Minnesota,</institution></institution-wrap>Minneapolis, 55455 USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Minneapolis</wicri:regionArea></affiliation></author><author><name sortKey="Blazar, Bruce R" sort="Blazar, Bruce R" uniqKey="Blazar B" first="Bruce R." last="Blazar">Bruce R. 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While much is known about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migration. We established an <italic>in vitro</italic> system to evaluate lymphatic TEM for various cell types across primary mouse and human lymphatic endothelial cells (LEC), and validated the model for the murine LEC cell line SVEC4-10. T cells exhibited enhanced unidirectional migration from the basal (abluminal) to the apical (luminal) surface across LEC, whereas for blood endothelial cells (BEC) they migrated similarly in both directions. This preferential, vectorial migration was chemotactic toward many different chemoattractants and dose-dependent. Stromal protein fibers, interstitial type fluid flow, distribution of chemokines in the stromal layer, and inflammatory cytokines influenced LEC phenotype and leukocyte TEM. Activated and memory CD4 T cells, macrophages, and dendritic cell (DC) showed chemoattractantΔdriven vectorial migration, while CD8 T cell migration across LEC was not. The system was further validated for studying cancer cell transmigration across lymphatic endothelium. This model for lymphatic TEM for various migrating and endothelial cell types possesses the capacity to be high-throughput, highly reproducible and integrate the complexities of lymphatic biology, stromal variability, chemoattractant distribution, and fluid flow.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Platt, Am" uniqKey="Platt A">AM Platt</name></author><author><name sortKey="Randolph, Gj" uniqKey="Randolph G">GJ Randolph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, M" uniqKey="Weber M">M Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Czeloth, N" uniqKey="Czeloth N">N Czeloth</name></author><author><name sortKey="Bernhardt, G" uniqKey="Bernhardt G">G Bernhardt</name></author><author><name sortKey="Hofmann, F" uniqKey="Hofmann F">F Hofmann</name></author><author><name sortKey="Genth, H" uniqKey="Genth H">H 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Madlener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giampieri, S" uniqKey="Giampieri S">S Giampieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, G" uniqKey="Schneider G">G Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratajczak, Mz" uniqKey="Ratajczak M">MZ Ratajczak</name></author><author><name sortKey="Suszynska, M" uniqKey="Suszynska M">M Suszynska</name></author><author><name sortKey="Borkowska, S" uniqKey="Borkowska S">S Borkowska</name></author><author><name sortKey="Ratajczak, J" uniqKey="Ratajczak J">J Ratajczak</name></author><author><name sortKey="Schneider, G" uniqKey="Schneider G">G Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ray, P" uniqKey="Ray P">P Ray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name></author><author><name sortKey="Lund, Aw" uniqKey="Lund A">AW Lund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fontenot, Jd" uniqKey="Fontenot J">JD Fontenot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sugarman, Bj" uniqKey="Sugarman B">BJ Sugarman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cailleau, R" uniqKey="Cailleau R">R Cailleau</name></author><author><name sortKey="Young, R" uniqKey="Young R">R Young</name></author><author><name sortKey="Olive, M" uniqKey="Olive M">M Olivé</name></author><author><name sortKey="Reeves, Wj" uniqKey="Reeves W">WJ Reeves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hippen, Kl" uniqKey="Hippen K">KL Hippen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Xiong, Yanbao" sort="Xiong, Yanbao" uniqKey="Xiong Y" first="Yanbao" last="Xiong">Yanbao Xiong</name></noRegion><name sortKey="Blazar, Bruce R" sort="Blazar, Bruce R" uniqKey="Blazar B" first="Bruce R." last="Blazar">Bruce R. Blazar</name><name sortKey="Brinkman, C Colin" sort="Brinkman, C Colin" uniqKey="Brinkman C" first="C. Colin" last="Brinkman">C. Colin Brinkman</name><name sortKey="Bromberg, Jonathan S" sort="Bromberg, Jonathan S" uniqKey="Bromberg J" first="Jonathan S." last="Bromberg">Jonathan S. Bromberg</name><name sortKey="Bromberg, Jonathan S" sort="Bromberg, Jonathan S" uniqKey="Bromberg J" first="Jonathan S." last="Bromberg">Jonathan S. Bromberg</name><name sortKey="Bromberg, Jonathan S" sort="Bromberg, Jonathan S" uniqKey="Bromberg J" first="Jonathan S." last="Bromberg">Jonathan S. Bromberg</name><name sortKey="Hippen, Keli L" sort="Hippen, Keli L" uniqKey="Hippen K" first="Keli L." last="Hippen">Keli L. Hippen</name><name sortKey="Lord, Colin J" sort="Lord, Colin J" uniqKey="Lord C" first="Colin J." last="Lord">Colin J. Lord</name><name sortKey="Mongodin, Emmanuel F" sort="Mongodin, Emmanuel F" uniqKey="Mongodin E" first="Emmanuel F." last="Mongodin">Emmanuel F. Mongodin</name></country><country name="Canada"><noRegion><name sortKey="Famulski, Konrad S" sort="Famulski, Konrad S" uniqKey="Famulski K" first="Konrad S" last="Famulski">Konrad S. Famulski</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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